10 octobre 2017 par maty185
The breakthrough research came from the Medical Research Council Toxicology Unit, based at the University of Leicester. A team of scientists analyzed the way viruses attack a group of brain cells and force the production of viral defense proteins, which sometimes get produced as faulty “misfolded” proteins. These misfolded proteins do more damage than the regular defense mechanisms, lingering in the brain cells longer and sapping neurons of their ability to function. The cell essentially starves, and, when replicated across many, many neurons, brain functions deteriorate in the process.
In the end, mice that didn’t receive the compound saw continued cellular breakdown and often died within 12 weeks. Meanwhile, those that had received it saw neurodegeneration come to a halt and survived with healthy brain tissue for the duration of the study.
« They were absolutely fine, it was extraordinary,” said lead researcher, Prof. Giovanna Mallucci, to the BBC. « This isn’t the compound you would use in people, but it means we can do it and it’s a start. »