Des chercheurs identifient de nouvelles substances liées au risque de développer la maladie d’Alzheimers ou la démence

12 juin 2017 par maty185

Researchers identify new circulating compounds linked to risk of developing AD and dementia:

http://www.news-medical.net/news/20170612/Researchers-identify-new-circulating-compounds-linked-to-risk-of-developing-AD-and-dementia.aspx

Many routes to anthranilic acid have been described. Industrially it is produced from phthalic anhydride, beginning with amination.

Biosynthesis

Anthranilic acid is biosynthesized from chorismic acid. It is the precursor to the amino acid tryptophan via the attachment of phosphoribosyl pyrophosphate to the amine group.

Uses

Industrially, anthranilic acid is an intermediate in the production of azo dyes and saccharin. It and its esters are used in preparing perfumes to imitate jasmine and orange, pharmaceuticals (loop diuretics e.g. furosemide) and UV-absorber as well as corrosion inhibitors for metals and mold inhibitors in soy sauce.

Anthranilic acid can be used in organic synthesis to generate benzyne.[9] The benzyne rapidly dimerizes to form biphenylene.

Chlorination of anthranilic acid gives the 2,4-dichloro derivative.[10]

Anthranilate-based insect repellents have been proposed as replacements for DEET.

Fenamic acid is a derivative of anthranilic acid,[11]:235 which in turn is a nitrogen isostere of salicylic acid, which is the active metabolite of aspirin.[11]:235 Several non-steroidal anti-inflammatory drugs, including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid are derived from fenamic acid or anthranilic acid and are called « anthranilic acid derivatives » or « fenamates ».[12]:17

https://en.wikipedia.org/wiki/Anthranilic_acid

https://en.wikipedia.org/wiki/Category:Anthranilic_acids

Phthalate:  https://en.wikipedia.org/wiki/Phthalate

Les 13 perturbateurs endocriniens à éviter en cosmétique

http://www.oolution.com/bloog/blog/2014/02/13/les-13-perturbateurs-endocriniens-eviter-dans-nos-cosmetiques/

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